Environmental Epigenetics


The Bhandari lab studies early development of the vertebrate gonads, using the medaka embryo as an in vivo genetic model system for understanding mechanisms of germ and somatic cell development. Understanding of basic mechanisms of gonad development is critical for understanding any abnormalities that initiate during early development and leads to reproductive failure at adulthood. Reproductive failure can have consequences at a population level.

The cells in the developing gonads are susceptible to environmental stress and consquences of exposure to these stressors are not limited to reproductive failure but a variety of diseases at the somatic and germ cell level in offspring across several genereations. Following are the research topics: 

a) The mechanisms of germ and supporting somatic cell development in the gonads of developing embryos

b) How environmental stressors, especially chemicals that humans and wildlife are exposed to, interact with molecular pathways and alter developmental trajetories in germ cells taking comparative, molecular, cellular, and bioinformatic analysis approaches.

c) Mechanisms underlying transgenerational inheritance of environmentally induced health effects

e) Epigenetic landsacpe of the brain cells that produce estrogens and epigenetic alterations induced by environmental endocrine disruptors.

d) Effects of these chemical stressors in humans at the cellular and molecular level using  an in vitro cell coculture technique. 

Lab address
114 Eberhart Bldg
Phone: 336.256.1006   

Fish Husbandry
104 Eberhart Bldg

gBhandari's Office
405 Eberhart Bldg
Phone: 336.256.0493   

"Our lab conducts both field- and laboratory-based experiments and utilizes cell/tissue culture, fish, turtles, birds, and rodents as models"

- Ramji Bhandari 

"Our  lab is a part of Environmental Health Sciences Graduate Program at the UNCG Department of Biology . Our graduate students have opportunities to specialize in a wide ranges of topics from ecosystem health to transgenerational organismal health "


Mailing address
University of North Carolina at Greensboro
312 Eberhart Bldg, 321 McIver St
Greensboro, NC 27402-6170
Phone: 336.256.0493 Voice | Fax: 336.334.5839