University of North Carolina at Greensboro
312 Eberhart Bldg, 321 McIver St
Greensboro, NC 27412
Phone: 336.256.0493 Voice | Fax: 336.334.5839
"Our lab is a part of Environmental Health Sciences Graduate Program at the UNCG Department of Biology. Our graduate students have opportunities to specialize in a wide ranges of topics from ecosystem health to transgenerational organismal health "
The Bhandari lab studies early development of the vertebrate gonads, using the medaka embryo as an in vivo genetic model system for understanding mechanisms of germ and somatic cell development. Understanding of basic mechanisms of gonad development is critical for understanding any abnormalities that initiate during early development and leads to reproductive failure at adulthood. Reproductive failure can have consequences at a population level.
The cells in the developing gonads are susceptible to environmental stress and consequences of exposure to these stressors are not limited to reproductive failure but a variety of diseases at the somatic and germ cell level in offspring across several generations. We are striving to explore:
a) The mechanisms of germ and supporting somatic cell development in the gonads of developing embryos;
b) How environmental stressors, especially chemicals that humans and wildlife are exposed to, interact with molecular pathways and alter developmental trajectories in germ cells taking comparative, molecular, cellular, and bioinformatic analysis approaches;
c) Mechanisms underlying transgenerational inheritance of environmentally induced health effects;
e) Epigenetic landscape of the brain cells that produce estrogens and epigenetic alterations induced by environmental endocrine disruptors in the brain; and
d) Effects of these chemical stressors in humans at the cellular and molecular level using an in vitro cell coculture technique.
114 Eberhart Bldg
405 Eberhart Bldg
PO Box: 27402-6170
"Our lab conducts both field- and laboratory-based experiments and utilizes cell/tissue culture, fish, turtles, birds, and rodents as models"
- Ramji Bhandari
"Our interest is to understand how environmental stressors affect health and how these effects are inherited by offspring across many generations"